Showing posts with label Health News. Show all posts
Showing posts with label Health News. Show all posts
Wolbachia Bacteria Could Be Answer To Malaria, Dengue: Bill Gates

Wolbachia Bacteria Could Be Answer To Malaria, Dengue: Bill Gates

Wolbachia Bacteria Could Be Answer To Malaria, Dengue: Bill Gates
A bacteria called Wolbachia could be the answer to dreaded mosquito-borne diseases like malaria and dengue, Microsoft founder and philanthropist Bill Gates has said.


 


"There are a couple of ideas for changing the mosquito that we've been funding in order to work on dengue and malaria," Mr Gates said.

"One idea is that you actually put a bacteria called, 'Wolbachia' into the mosquito, and then it doesn't carry the parasite hardly at all. So, we've done field trials on that. And it appears that also does work for dengue. It appears it also works for Zika," he said.



"So, that may get rolled out more quickly and even more powerful tool that spreads faster but more controversial is to take our new gene-editing technology that people call crisper, and have male and female mosquitoes pass along either something that prevents them from carrying the virus or something that kills the progeny," he said.


"Those are both approaches, but use geniality and then create a thing called gene drive which means that all of your children, both male and female inherit something even if only one of your parents have it. That it's dominant into that generation, either to not survive or not carry the bad virus," he added.


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Mr Gates said every year more than 60,000 kids die of malaria which are mosquito-caused death, that is the animal that generates the most mortality. 
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Source: NDTV 
Link made between genetics, aging

Link made between genetics, aging


Scientists at the University of Georgia have shown that a hormone instrumental in the aging process is under genetic control, introducing a new pathway by which genetics regulates aging and disease.
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Previous studies have found that blood levels of this hormone, growth differentiation factor 11, decrease over time. Restoration of GDF11 reverses cardiovascular aging in old mice and leads to muscle and brain rejuvenation, a discovery that was listed as one of the top 10 breakthroughs in science in 2014.
Scientists in the UGA College of Family and Consumer Sciences have now discovered that levels of this hormone are determined by genetics, representing another potential mechanism by which aging is encoded in the genome.
Future studies will seek to reveal why GDF11 levels decrease later in life and whether they can be sustained to prevent disease.
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"Finding that GDF11 levels are under genetic control is of significant interest. Since it is under genetic control, we can find the genes responsible for GDF11 levels and its changes with age," said the study's senior author Rob Pazdro, an assistant professor in the college's department of foods and nutrition.
The study confirmed results from previous experiments showing that GDF11 levels decrease over time and also showed that most of the depletion occurs by middle age.
In addition, the study examined the relationship between GDF11 levels and markers of aging such as lifespan in 22 genetically diverse inbred mice strains. Of note, the strains with the highest GDF11 levels tended to live the longest.
Using gene mapping, Pazdro's team then identified seven candidate genes that may determine blood GDF11 concentrations at middle age, demonstrating for the first time that GDF11 levels are highly heritable.
"Essentially, we found a missing piece of the aging/genetics puzzle," Pazdro said. "Very generally, we've made an important step toward learning about aging and why we age and what are the pathways that drive it. It's the first step down a long road, but it's an important step."
The study, "Circulating Concentrations of Growth Differentiation Factor 11 are heritable and correlate with life span," was published in the Jan. 16 issue of the Journals of Gerontology Series A Biological Sciences and Medical Sciences.

Source:sciencedaily.com